The game walked away with four awards out of 17 total categories, including Ultimate Game of the Year.
The Edge Most Wanted Award went to Fallout 3.
Other notable titles that scooped a Golden Joystick include Grand Theft Auto IV, Super Smash Bros. Brawl and Metal Gear Solid 4.
The Golden Joysticks are in their 26th year, and are organized by Future, publisher of Edge.
Winners were determined by votes from gamers, which totaled over 850,000.
Complete results are below.
Edge Most Wanted Award
Fallout 3 - Bethesda
The Sun Family Game of the Year
Guitar Hero III - Activision
Bliss Handheld Game of the Year
Zelda: Phantom Hourglass - Nintendo
Activision Blizzard Retailer of the Year
Play.com
E4 Talent Mobile Game of the Year
Bejeweled 2 - PopCap
Nuts All-Nighter Multiplayer Game of the Year
Call of Duty 4: Modern Warfare - Activision
BBC1Xtra Soundtrack of the Year
Grand Theft Auto IV - Take-Two
Nintendo Game of the Year (Sponsored by Official Nintendo Magazine)
Super Smash Bros. Brawl - Nintendo
ARVATO Xbox Game of the Year
Grand Theft Auto IV - Take-Two
PlayStation Game of the Year (Sponsored by Official PlayStation Magazine HD)
Metal Gear Solid 4 - Konami
PC Game of the Year (Sponsored by The United Kingdom e-sport Association)
Call of Duty 4: Modern Warfare - Activision
Play.com One to Watch Award
Call of Duty: World at War - Activision
CVG.co.uk UK Developer of the Year
Rockstar Games
Publisher of the Year
Activision
E4.com Grand Master Flash Award
Stickman Madness - Gaumina
Games Radar Online Game of the Year
Call of Duty 4 - Activision
Virgin Media Ultimate Game of the Year
Call of Duty 4: Modern Warfare - Activision