The Microsoft published game knocked Lego Harry Potter: Years 1-4 from the top spot after two weeks.
Red Dead Redemption dropped a spot to third, ahead of Dance On Broadway, which was up two places, and non-mover 2010 FIFA World Cup South Africa in fifth.
PokePark Wii: Pikachu's Adventure was the only other new release to make the top 40, placing at 25.
01. Crackdown 2 (Microsoft)
02. Lego Harry Potter: Years 1-4 (Warner)
03. Red Dead Redemption (Rockstar)
04. Dance On Broadway (Ubisoft)
05. 2010 FIFA World Cup South Africa (EA)
06. Super Mario Galaxy 2 (Nintendo)
07. Tiger Woods PGA Tour 11 (EA)
08. Call Of Duty: Modern Warfare 2 (Activision)
09. Just Dance (Ubisoft)
10. UFC 2010: Undisputed (THQ)
Source: Chart-Track
UK chart history