Cain was the producedr and designer for the revered RPG Fallout, and aided with the initial design for Fallout 2.
At NCsoft-owned Carbine, he'll lead the design of an upcoming unannounced MMO.
Cain, who also co-founded the now-defunct Troika Games, has been with Carbine since the studio's founding in 2005, serving as programming director.
Carbine executive producer Jeremy Gaffney said in a statement, “Tim is one of the most respected guys in the business and his track record of creating hit products is well documented. Having Tim at the helm as design director makes an already strong team that much better.”